Ciprofloxacin - Best antibiotic

        INTRODUCTION:

        Ciprofloxacin Hydrochloride is a second-generation fluoroquinolone antibiotic used to treat infections caused by bacteria      such as pneumonia; bronchitis; prostatitis, anthrax, chancroid; gonorrhea; endocarditis, gastroenteritis and ear, lung, throat, and urinary tract infections. Antibiotics will not work for colds, flu, or other viral infections. Chemically, Ciprofloxacin Hydrochloride is, 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride, monohydrate. Its molecular formula is C₁₇H₁₈FN₃O₃·HCl·H₂O, and it has a molecular weight of 385.82.After oral administration, Ciprofloxacin given as an oral tablet is rapidly and well absorbed from the gastrointestinal tract after oral administration. 

The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism. Ciprofloxacin maximum serum concentrations and area under the curve are shown in the chart for the 250 mg to 1000 mg dose range. 

The pharmacokinetics of Ciprofloxacin in the urine of pediatric patients has not been studied at this time. Until further data are available, the renal pharmacokinetic properties of Ciprofloxacin Hydrochloride established in adults should not be extrapolated to pediatric patients. Because Ciprofloxacin Hydrochloride is renaly excreted, the serum half-life is prolonged in patients with reduced renal function. 

INDICATION:

Ciprofloxacin is used to treat a number of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid, as well as:

·         Urinary tract infections (recommended as a first-line antibiotic)

·         Chronic bacterial prostatitis (recommended as a first-line antibiotic choice)

·         Lower respiratory tract infections (not recommended as a first-line antibiotic choice)

·         Acute sinusitis (not recommended as a first-line antibiotic choice)

·         Skin and skin structure infections

·         Bone and joint infections

·         Infectious diarrhea

SIDE EFFECTS:

Diarrhea, fever, sore throat and headache, pale or yellowed skin, dark colored urine, fever, weakness, seizure (convulsions), nausea, vomiting, stomach, pain, dizziness, insomnia, numbness, tingling, or unusual pain anywhere in your body

CONSTITUENTS:

Active Substance:

Active ingredient of Xylobox Powder for Suspension 60 ml is Ciprofloxacin Hydrochloride.

CAS Registry Number: [86393-32-0]

               

 Physical Characteristics of Active Substance:

Ciprofloxacin Hydrochloride is a faintly yellowish to light yellow crystal. Sparingly soluble in water, slightly soluble in acetic acid and methanol, very slightly soluble in dehydrate alcohol, practically insoluble in acetone, in acetonitrile, in ethyl acetate, in hexane, and in methylene chloride.

Compatibility:

As the product is designed for single active substance the incompatibility with other active substances does not arise in this preparation. The active material, Ciprofloxacin Hydrochloride is not incompatible with other excipients used in the formulation.