Thursday, November 22, 2012

AROMATIC WATERS


AROMATIC WATERS

Definition:
Aromatic waters are clear, saturated solutions of aromatic substances (may be volatile oils or volatile solids) in water. Their flavors and taste are similar to the corresponding aromatic substances used.
Use:
(i)       They are mainly used as the vehicle for oral liquid preparations due to their flavoring properties. E.g. Peppermint Water  IP.
(ii)     Some aromatic waters have preservative action, hence are used as menstruum to extract crude drugs. E.g. Chloroform Water IP.
(iii)    Some aromatic waters have mild therapeutic action. E.g. Camphor Water IP has carminative action, Anise Water has carminative and mild expectorant action.

Methods of Preparations

(a)     Solution method
(i)             The volatile oil is shaken with 500 times its volume of Purified Water IP.
(ii)           The mixture is shaken for a period of 30 minutes.
(iii)          The mixture is set aside for 12 hours or overnight.
(iv)         Filtered.
(b)     Using distributing agents
(i)             The volatile oil is triturated with a sufficient quantity of powdered talc or kieselghur, or pulped filter paper in a mortar.
(ii)           Purified Water IP 500 times the volume of oil is taken and mixed.
(iii)          The solution is filtered.

N.B. Talc, kieselghur, pulp of filter paper are called distributing agents. The volatile oils get adsorbed on the particle surface and a large surface area helps in quick dissolution of the oil into water.

(c)     Dilution from cnocentrated preparations
(i)             A concentrated aromatic water is prepared as per the formula given in the pharmacopoeia.
(ii)           One ml of concentrated aromatic water is diluted with 39 ml of Purified Water IP and mixed.

Examples of various Aromatic Waters

Name of Aromatic Water
Name of Concentrated Aromatic Water
Dilution
Use
Conc. Arom. Water
Purified Water
Anise Water
Concentrated Anise Water
1ml
39ml
Flavor, Carminative, Mild expectorant
Camphor Water
Concentrated Camphor Water
1ml
39ml
Flavor, Carminative, Mild expectorant
Caraway Water
Concentrated Caraway Water
1ml
39ml
Flavor, Carminative
Chloroform Water
Chloroform Water Double Strength (DS)
1ml
39ml
Preservative, Flavor
Cinnamon Water
Concentrated Cinnamon Water
1ml
39ml
Flavor, Carminative
Dil Water
Concentrated Dil Water
1ml
39ml
Flavor, Carminative (particularly for infants in gripe water)
Peppermint Water
Concentrated Peppermint Water
1ml
39ml
Flavor, Carminative, Weak Preservative
Formulae of different aromatic waters available in IP 1966
Name of the Aromatic water
Formula
Method of preparation
Chloroform Water IP66
Chloroform 2.5 ml
Purified water upto 1000ml
Solution method.
Camphor Water IP66
Camphor 1gm
Alcohol (90%v/v)
Purified Water 1000ml
Camphor is dissolved in alcohol and the alcoholic solution is added to purified water drop-wise. The mixture is shaken well. N.B. Water should not be added to the alcoholic solution.
Concentrated Peppermint Water BPC
Peppermint oil 20ml
Alcohol (90%v/v) 600ml
Purified Water upto 1000ml
Peppermint oil is dissolved in alcohol. Purified water is added in small amount to the alcoholic solution and shaken vigorously. Suitable amount of talc is dispersed in the solution to adsorb the excess oils. Finally the solution is filtered.

No comments:

Post a Comment